Hello,
There are so many ebay sellers selling the newer mercedes navigation systems that are a lot bigger than mine and have usb and auxilary!

my 2000 s430 has an old school navigation without anything fancy and no USB input :-( Some people say its a 50/50 chance that it'll work, but i want to know from you guys:

I want to replace my older navigation system, SO can I buy a newer navigation system on ebay and try to install it to my s430? all the gadgets look pretty compatible and the new screen is so much bigger!

Here's the link that says it'll work in my s430:
Car GPS Navigation Touch Screen DVD Radio for 1999 06 Mercedes Benz s Class W220 | eBay

 

Doesn't look like plug n' play, are you planning on installing this yourself? I'd look more along the lines of this: Mercedes W220 SAT Nav DVD TV Screen Display Comand A 2208205889 7612500040 | eBay then gathering the rest of the parts here for the proper retrofit: My Comand 16x9 facelift retrofit on my S55 AMG. - MBWorld.org Forums

 

Can't figure out how to enter my own POI for my 2010 GLK350 -
Command **** being useless while driving - never buy another MB if this is SOP

 

Any luck with Nav/Entertainment upgrade. I purchased a 2000 S 5000 several months back and am interested in upgrading as well. Let me know if you tried it and your success. If you haven't given it a shot yet, let me know as well and I will let you know if it works for me.