I have a 2016 E350 with 69k miles. Was on the interstate yesterday 50 miles from home cruising at 80 mph when felt a vibration similar to a wheel out of balance. Would come and go every few seconds and then check engine light came on. Pulled over and was running rough even at idle. Stopped and then restarted. Ran fine. Checked this morning and no codes showing. Any suggestions?

 

I have the same car and the same issue. I replaced the spark plugs and coils, problem solved.